Sheldon Jackson (1834 -1909) was a pioneering missionary in the American West. In 1890 Jackson discovered that Eskimos were facing slow starvation, partly because of destruction of their food supplies by whalers. Learning that the Siberians on the Russian side of the Bering Strait had an unfailing food supply of reindeer, Jackson introduced reindeer to Alaska.
Dr. Eugene R. Kellersberger (1888-1966) was a Presbyterian minister and medical missionary to the Congo from 1916 to 1953. Dr. Kellersberger founded the Bibanga Medical School and Hospital and the Bibanga Agricultural Colony for lepers, bringing about a better understanding of leprosy.
William H. Sheppard (1865-1927) was the first African-American Presbyterian missionary to the Congo, serving from 1890 to 1910. He fought for better working conditions for Congolese rubber workers.
Carroll R. Stegall (1891-1965) was appointed by the Executive Committee of Foreign Missions of the Presbyterian Church in the U.S. in 1915 to be a lay missionary for the American Presbyterian Congo Mission. He was stationed at Luebo and later at Lubondai, both in the province of Kasai. In the 1930s, Stegall operated a radio transmitter, powered by a hand-cranked generator, from the mission station at Luebo. With the onset of war in Europe in 1939, the transmitter was shut down under an order from the Belgian government that all amateur stations cease operation.
Three generations of the Vass family served the Presbyterian Church, both in the United States and in the Congo, during the nineteenth and twentieth centuries. Lachlan Cumming Vass I ministered in the U.S. South between 1860 and 1896. His son and grandson, Lachlan Cumming Vass II and Lachlan Cumming Vass III, both served at the American Presbyterian Congo Mission (APCM). Vass III's wife, Winifred (Kellersberger), served with her husband at the APCM, and later published several books and articles on the history of the Presbyterian Church in the Belgian Congo/Zaire.